Real Madrid defeated Barcelona 2–1 in a match during the 10th round of the Spanish championship. The game took place on October 25 at the Camp Nou stadium.

The visitors took the lead in the 41st minute, with Kylian Mbappé opening the scoring following a deflection. In the 61st minute, Raphinha equalized, converting a pass from Pedri. The winning goal came in the 87th minute, once again from Mbappé, who was set up by substitute Eduardo Camavinga. For the Frenchman, this goal marked his 11th of the current La Liga season.

Barcelona held more possession (62% to 38%) and registered more shots (16 to 9), but could not hold on for a draw. This marks a second consecutive defeat for the Catalans, who had won all nine of their league matches leading up to El Clásico.

After 10 rounds, Barcelona remains the leader with 27 points, while Real Madrid has 24 points. The teams' next league encounter is scheduled for May 9, 2027, at the Santiago Bernabéu.